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Modulation of Inflammatory Pathways GLP-1 receptor agonists work through sophisticated anti-inflammatory mechanisms: Modulation of the nuclear factor-kappa B (NF-B) pathway Reduction of inflammatory cytokine production Attenuation of oxidative stress Activation of the cAMP-PKA-dependent signaling pathway, which is crucial for anti-inflammatory effects 3

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Most individuals begin to see results within the first few weeks of treatment, but significant weight loss typically occurs over several months

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They did however comment in their New England Journal of Medicine article that the affinity of lixisenatide for the GLP-1 receptor was up to four times greater than that of human GLP-1and there have been neuroprotective actions shown in animal models of Alzheimers disease. Together, I suspect these were likely strong rationales driving their choice of the use of Lixisenatide