Studies on growth hormone secretagogue withdrawal show that prolonged exogenous stimulation can temporarily downregulate natural GH pulse frequency and amplitude
Metformin promotes ferroptosis and sensitivity to sorafenib in hepatocellular carcinoma cells via ATF4/STAT3
1 Introduction Acute Mountain Sickness (AMS) is a common and potentially debilitating condition that affects individuals ascending to altitudes above 2,500 m above sea level ( 2 ), a condition known as hypobaric hypoxia ( Notably, studies have established that exposure to hypobaric hypoxia promotes a redox imbalance, leading to an exacerbated increase in reactive oxygen species (ROS) along with deterioration of endogenous antioxidant defenses ( 2 O 2 ) in exhaled breath condensate (EBC), both at rest and during exercise at altitude, correlating with decreased arterial oxygen saturation and AMS symptom severity ( Based on these findings, various studies have proposed antioxidant use as a preventive therapeutic strategy, given that the only pharmacological treatment currently employed to mitigate AMS is acetazolamide, along with anti-inflammatory agents such as dexamethasone and ibuprofen
p53: protection against tumor growth beyond effects on cell cycle and apoptosis
Kramer CM, Borlaug BA, Zile MM, et al
