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Although the absolute risk remains relatively low, studies show a modest but consistent increase in gallstones and cholecystitis among treated patients compared to placebo

Besides, proteasome dysfunction in PD also triggers the development of oxidative stress with progressive neuronal injury (Nishida et al

Patients with pre-existing conditions such as polycystic ovary syndrome (PCOS) or thyroid disorders may be particularly susceptible to hair changes during weight loss treatment, though the evidence linking other hormonal shifts directly to hair loss is limited

Dysesthesia is the most distinctive and least understood side effect of retatrutide