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A novel dual GLP-1 and GIP receptor agonist is neuroprotective in the MPTP mouse model of Parkinsons disease by increasing expression of BNDF

GLP-1 use has surged in recent years, with one recent poll estimating that one in eight adults nationwide has used the drugs to fight weight loss, treat diabetes or prevent heart attacks and strokes

Disruption of insulin signaling is directly related to the activation of mechanisms involved in the progression of the neurodegenerative process

Another study compared patients with obesity and hypothalamic damage, patients without obesity and hypothalamic damage, controls with obesity and normal-weight controls (Steele et al., 2015)