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Furthermore, omega-3 PUFAs and their metabolites (i.e., specialized pro-resolvin mediators), could effectively ameliorate uncontrolled inflammatory responses, reduce OxS, mitigate coagulopathy, and restore tissue homeostasis 715

Int J Colorectal Dis

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Furthermore, melatonin combined with a ketogenic diet overcomes drug resistance to cisplatin and vincristine in BC-bearing mice by inducing apoptosis, inhibiting angiogenesis, lowering blood glucose, increasing ketone bodies, and downregulating resistance genes, achieving cure rates up to 70% 168

For instance, treatment with MEK inhibitors can lead to the activation of the IL6/JAK/STAT3 signaling pathway in tumor cells, enabling them to sustain survival and proliferation despite the inhibitory effects of the drug [5]