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HUVECs, in particular, act as semi-professional antigen-presenting cells, expressing major histocompatibility complex (MHC) class I constitutively and MHC class II in an inducible manner, thus potentially enhancing T-cell activation and distorting disease modelling (199, 200)

61 Many of those experiments that had trouble finding an increase in TMAO after carnitine challenges lacked adequate timing or used only a moderate amount of red meat, whereas studies that included a significant carnitine load from red meat have shown clearer TMAO elevation

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The first nootropic to use the term was a drug developed in the 1960s called piracetam.60 61 It was intended to treat anxiety and provide patients with a soothing experience that might even lull them to sleep.2 The effect was quite different than what its creators intended, as users reported sharper focus, and later testing pointed toward improved memory

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