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16 Demonstrated clinical benefits of GLP-1s include improved cardiometabolic risks, fewer major adverse cardiovascular events, 22 decreased mortality in heart failure, 23-27 and improvements in obstructive sleep apnea, 11,28 prediabetes, 29,30 chronic kidney disease, 31 knee osteoarthritis, 32 substance use disorders, 33 and metabolic-associated steatotic liver disease
Finally, agent selection is influenced by insurance formulary and cost
Acknowledgements The authors would like to thank Xiaotong Zhangs lab at Zhejiang University for the technical support in data acquisition
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Although early pharmacovigilance reports suggested a possible association with suicidality, larger subsequent studies have not demonstrated a causal link, though ongoing monitoring remains advisable
