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Moreover, in situ imaging of GSH in living cells could boost the monitoring of the distribution and dynamical expression of GSH and research on GSH-related cellular processes and diseases

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457 However, dual MEK/AKT inhibition with Trametinib and GSK2141795 did not yield clinical benefits in metastatic NRAS -mutant and wild-type melanoma, 458 indicating the limited spectrum of application of AKTi in melanoma with rather high heterogeneity

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