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Its cyclic structure and receptor selectivity make it a valuable research tool for examining intracellular signaling networks and receptor-mediated communication pathways

Especially, the release of IL-17, by Th17, triggers the expression of inducible nitric oxide synthase (iNOS) and concomitant increase of nitric oxide (NO) in various cell types and activates many other inflammatory mediators (Mahad et al., 2008)