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The main function of GLP-1 is that it activates insulin secretion from beta cells and inhibits glucagon secretion from alpha cells [20]

Design In the obesity trial, 338 participants (mean age 48 years, 48% women, mean BMI 37.3 kg/m 2 ) were randomised (2:1:1:1:1:2:2) to retatrutide 1 mg, 4 mg (titration), 4 mg (no titration), 8 mg (slow titration), 8 mg (fast titration), 12 mg or placebo over 48 weeks [45]

You may experience water retention, increased appetite, or a temporary stall in progress, but the metabolic changes from weeks of consistent therapy remain

Habitual dietary intake of IBD patients differs from population controls: a case-control study