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It has been suggested that in the body it complexes with carrier proteins to prevent degradation, or exists as a component of a large precursor molecule, but as yet no structure or gene has been found for this precursor.Evidence supports the current belief that it is regulated by glucocorticoids

doi: 10.1016/j.freeradbiomed.2018.05.074 237 HuangZGanSZhuangXChenYLuLWangYet al

Small molecule erastin can directly and selectively target and inhibit the System X c , and irreversibly bind to and inactivate XCT, leading to continuous disorder of cystine uptake, a decrease in cellular antioxidant capacity, and eventually ROS accumulation and ferroptosis (Sato et al., 2018

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Analytical application Finally, we examined whether the assay can be used to detect increased LOXs activity in pathologic specimens