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& Martins, L

Currently, the main limitation of organoids in terms of cellular complexity is the apparent lack of luminal cells and associated spatial organization

The bacterium secretes a chemotactic factor for neutrophils and monocytes [8,9], resulting in their activation and the generation of reactive oxygen species (ROS) including superoxide anion and hydroxyl radicals , hydrogen peroxide and hypochlorous acid [10,11]

Furthermore, numerous studies face challenges due to limited sample sizes, short follow-up periods, and variations in fasting protocols, making direct comparisons among them difficult