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Curcumin , some preclinical evidence suggests curcumin may upregulate GLP-1 secretion, though human data is limited

Applying the patch for longer periods can lead to side effects such as: Erythema (redness) Pruritus (itching) Contact dermatitis Skin inflammation Burning sensation GLP-1 transdermal patches may also cause hypersensitivity reactions and skin sensitization after repeated exposure

M.LugertR.GroU.et al (2013)

Glucose-dependent insulinotropic polypeptide (GIP) is an incre- tin hormone that enhances meal-stimulated insulin secretion and has been shown to modulate glucagon secretion in a glucose- dependent manner to facilitate postprandial lipid clearance, and to regulate food intake (Christensen et al., 2011;Kim et al., 2007;Nauck and Meier, 2018)

There has been an instance wherein the unauthorized use of AOD-9604, among other peptidic chemicals, was discovered as part of an anti-doping probe