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5.2 Tirzepatide (SURMOUNT Trials) Tirzepatide demonstrated even greater mean weight loss in SURMOUNT trials. Findings included: Weight reductions exceeding 20% in some cohorts Dose-dependent gastrointestinal symptoms Lean mass reduction proportional to total weight loss Again, detailed micronutrient panels were not central trial endpoints

Subgroup analyses by drug type, duration of treatment, and patient characteristics similarly showed no concerning signals

Some data suggests that injecting before 8am may produce slightly lower post-prandial glucose levels compared to evening injections, with one analysis showing a 15% improvement in post-meal blood sugar management

The primary endpoint was the percent change in body weight at week 28

SGLT2-i are a relatively new class of antidiabetic drugs with an emerging role in cardio-nephroprotection