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This entry, however, requires a hormone known as insulin, which is produced by the pancreatic cells

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At a glance Drug class / triple agonist: GLP-1, GIP, and glucagon receptor agonist (investigational) Known direct interaction with B12 / none identified to date Indirect depletion risk / present when retatrutide is co-prescribed with metformin Metformin B12 depletion incidence / up to 30% of long-term metformin users show subnormal B12 levels Recommended baseline test / serum B12 (ideally holotranscobalamin) before starting Retest interval / every 12 months on metformin