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Disease severity plays a crucial rolepatients with more advanced type 2 diabetes or higher degrees of obesity typically require longer treatment durations and may need indefinite therapy

"Gastrointestinal tolerability of once-weekly semaglutide 2.4 mg in adults with overweight or obesity, and the relationship between gastrointestinal adverse events and weight loss." Diabetes, Obesity and Metabolism

J Neuroophthalmol 39(1):8293 De Simone R et al (2020) Headache in idiopathic intracranial hypertension A

B Previous amputation, prior foot ulcer, peripheral neuropathy, foot deformity, peripheral vascular disease, visual impairment, peripheral neuropathy (especially if on dialysis), poor glycemic control, and smoking all represent high risk

DOI: 10.1152/ajpregu.00520.2015, Gentinetta, S., Sottotetti, F., Manuelli, M., and Cena, H