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While this sample size may seem small, it is not unusual for crossover studies, where each participant serves as their control, allowing for more robust within-subject comparisons despite a smaller overall sample

doi: 10.1016/j.physbeh.2013.05.028

Clinical vigilance is warranted when administering: Narrow therapeutic index drugs Time-sensitive medications such as antibiotics Oral contraceptives in specific scenarios 11.3 Concomitant Use with Insulin Therapy Combined use with insulin enhances glycemic control but necessitates cautious titration

This conversation can frame whether the switch aims to optimize receptor engagement, reduce side effects, or explore alternative metabolic targets