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This fundamental function in actin cytoskeleton regulation gives it a central role in cell motility, morphogenesis, and tissue repair processes

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Pancreatic beta cell dedifferentiation as a mechanism of diabetic beta cell failure

after stimulation of SMase-dependent ceramide formation, assembly of the death-inducing signaling complex (DISC) and oligomerization of Fas receptor, as well as cleaved caspase-8 and caspase-3, were detected [130]