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PMID: 33493036 Packer M et al (2021): Effect of Empagliflozin on Worsening Heart Failure Events in Patients With Heart Failure and Preserved Ejection Fraction: EMPEROR-Preserved Trial

SELECT (2023) Semaglutide cut MACE by 20% in people with obesity but without diabetes

Patients with Hashimoto's thyroiditis who are considering GLP-1 medications should have a thorough discussion with their GP or endocrinologist

Common early experiences include: Reduced appetite : Many people notice decreased hunger and earlier satiety during meals within days of the first injection or dose Mild gastrointestinal symptoms : Nausea (affecting 2040% of patients), occasional vomiting, or changes in bowel habits are usually mild and transient Injection site reactions : Minor redness, itching, or discomfort at injection sites is common but typically resolves quickly Fatigue : Some individuals report feeling more tired initially as their body adjusts to reduced calorie intake By weeks 24 , appetite suppression typically becomes more pronounced, and patients often find it easier to adhere to portion control and dietary modifications

Eli Lilly reports that tirzepatide is in clinical trials for autoimmune conditions in patients with obesity or overweight