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Additionally, atrophic gastritisaffecting 1030% of people over 50impairs intrinsic factor production

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The pathophysiology of ALS is still unknown, but altered protein homeostasis has been suggested to be a key player (Wijesekera and Leigh 2009)

Individuals at higher risk include older adults with reduced stomach acid production, people with gastrointestinal conditions affecting absorption, strict vegans, and those taking medications like metformin or proton pump inhibitors

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