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The picture is complicated by several confounding factors: Weight loss itself is associated with improved mood and reduced depressive symptoms in many individuals Better glycaemic control may enhance overall wellbeing and reduce diabetes-related distress Selection bias may exist, as patients with severe mental health conditions might be less likely to be prescribed these medications initially Currently, there is no official indication for GLP-1 agonists in treating depression, and the MHRA has not licensed these medications for mental health conditions

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Targeting the incretin/glucagon system with dual-agonists Improved metabolic efficacy could therefore be achieved by combining multiple metabolic actions by pairing the well-established pharmacology of GLP-1 to GCG, a combination which at first glance does not appeal intuitively

doi: 10.1136/gut.2009.195370 197 HettaHFSiragNElfadilHSalamaAAljadrawiSFAlfaifiAJet al