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Educate patients and caregivers on how to recognize respiratory depression and emphasize the importance of calling 911 or getting emergency medical help right away in the event of a known or suspected overdose (see WARNINGS, Life-Threatening Respiratory Depression)

Experimental investigations have reported interactions with VEGFR2 phosphorylation, focal adhesion kinase (FAK) activation, ERK1/2 signaling, nitric oxide-associated pathways, and extracellular matrix regulatory networks