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One review recommended the following regimen for patients with valproic acid overdose: 100 mg/kg IV loading dose followed by 50 mg/kg (maximum of 3 grams) IV every 8 hours until the ammonia levels are decreasing and the patient is improving [3]

Clinical trials show continued loss is possible with higher doses or compound switches, often reaching 1522% total body weight reduction

GLP-1based therapies, already recommended in adults, are gaining traction in younger populations due to their glucose-lowering and weight-reducing effects

NICE diagnostics guidance DG34

This mode of administration can be inconvenient for some patients, as it requires injection equipment and adherence to proper technique