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In fact, many patients report improved mood and reduced anxiety once their weight stabilizes, partly because excess weight often contributes to depression and poor self-image

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The most significant change is that NICE now recommends triple first-line therapy, comprising modified-release metformin, an SGLT2 inhibitor and subcutaneous semaglutide (up to 1 mg weekly), in those with established ASCVD

Following an FDA nod for oral Wegovy in December 2025, alternatives now cater to individuals preferring tablets over injections

Baillie GL, Horswill JG, Anavi-Goffer S, Reggio PH, Bolognini D, Abood ME, et al