Formed by tightly apposed endothelial cells supported by pericytes and astrocytic end-feet, the BBB restricts the entry of most small molecules, biologics, and nearly all gene-editing constructs [139]
Additionally, a phase II study is assessing the long-term efficacy and tolerability of rogaratinib in patients who have received the drug in a previous clinical trial and are currently in the continuation phase (NCT04125693)
Over time, untreated rheumatoid arthritis causes joint damage and may result in serious disability
Safety Profile: While we wait for PDA human trials, its parent peptide, BPC-157, has shown a great safety profile in early studies with no reported bad side effects on major organs (brain, heart, liver, etc.)
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