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Glucagon-like peptide 1 receptor agonists: A medication for obesity management

reported that cleavage products derived from GLP-1 reduced tubulointerstitial renal damage, lowered the expression of tubular injury markers, and attenuated the renal accumulation of macrophages and T cells (Moellmann et al., 2018)

They are most intense during the first few weeks at each dose level and typically improve as the body adapts

If you are past the initial phase, have reached your target weight or a stable maintenance phase, and want to reduce frequency, discuss it with your provider

In phase 2b trials, a 54-week regimen of daily subcutaneous cotadutide injections (100, 200, or 300 g) significantly lowered HbA1c levels compared to placebo