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10 Researchers have documented: Reduced ATP production Elevated oxidative stress markers Abnormal lactate responses with exertion Impaired fatty acid oxidation Inflammatory cytokines directly disrupt mitochondrial respiration and increase reactive oxygen species

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Poster Session II - ACUTE ISCHEMIC STROKE MANAGEMENT 01.00 - ACUTE ISCHEMIC STROKE MANAGEMENT - 01.02 - ACUTE MANAGEMENT - Thrombolysis or thrombectomy P716 - ESOC25-2036 IMPACT OF ONSET MODE ON TENECTEPLASE FOR ISCHEMIC STROKE AT 4.5 TO 24 HOURS: A POST-HOC ANALYSIS OF THE TRACE-III TRIAL Zhixin Cao 1 , Jinfeng Yin 2 , Liyuan Wang 1 , Manjun Hao 1 , Shuangzhe Wu 1 , Yunyun Xiong 1,2 , Yongjun Wang 1,2 1 Beijing Tiantan Hospital, Capital Medical University, Beijing, China, 2 China National Clinical Research Center for Neurological Diseases, Beijing, China Background and Aims: Whether the efficacy and safety of tenecteplase is different in patients with wake-up and witnessed onset strokes remains uncertain

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