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Clinical trials show that discontinuing GLP-1 therapy leads to weight regain in approximately 70% of patients within one year, underscoring why these medications function best as long-term treatment rather than temporary interventions

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Fernandes-Santos C, Zhang Z, Morgan DA, Guo D-F, Russo AF, Rahmouni K

For other AOMs, it is suggested to stop treatment if weight loss of more than 5% has not been achieved after 12 weeks of treatment [9]

The other side is that we experience a fever, lethargy, muscles aches and more - thats the other side of the lever