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N Engl J Med 2013

The diabetes and obesity epidemics keep growing with each year of sedentary lifestyle and caloric excess in developing nations whose middle classes are expanding rapidly

A review of practical issues on the use of glucagon-like peptide-1 receptor agonists for the management of type 2 diabetes

Most GLP-1 side effects are gastrointestinalso why on Earth are you having bad breath

Both preclinical and clinical studies have demonstrated that GLP-1s modulate the gut microbiota composition by delaying gastric emptying and altering luminal glucose ( Firmicutes Lachnospiraceae and Clostridiales ), alongside an increase in Proteobacteria (e.g., Burkholderiales bacterium YL45 ) and Akkermansia muciniphila a species largely associated with high-fibre diets and mucosal barrier health (6971)