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Retatrutide targets GLP1 + GIP + glucagon, so some commentators have started calling it GLP3 to suggest a thirdgeneration medication. How Retatrutide Works: Triple Agonist Mechanism Retatrutide is being developed as a onceweekly injectable that activates GLP1, GIP, and glucagon receptors at the same time to influence appetite, blood sugar, and energy expenditure. GLP1 receptor activation Reduces appetite and food intake

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