Individual factors that influence results include baseline gut microbiome composition, current diet quality, physical activity level, stress and sleep patterns, hormonal status, and starting body composition
Importantly, the largest reductions in BMI were observed in the southern United States, which also reported the highest rates of GLP-1 RA dispensing claims (Rader et al., 2024), a geographic concordance that is consistent with a causal contribution of these pharmacotherapies to the observed population-level BMI decline
GI side effects have largely resolved
These drugs are increasingly recognized not only for their therapeutic benefits but also for their potential to prevent serious chronic conditions
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