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Genistein administration induced Nrf2 enhancement by activation/phosphorylation of keap1, sirt1, MAPK-ERK1/2, PKC, and estrogen receptor in other cells or tissues, such as: hippocampal tissue, hypothalamic paraventricular nucleus, ovary, and Caco-2 cells [131, 135,136,137]
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One of the main ways in which reduced glutathione supports balanced oxidation levels is by directly neutralizing reactive oxygen species (ROS) like superoxide and hydrogen peroxide
We found that expression of GPX4 was reduced after Cys 2 starvation and erastin treatment, further proving that ferroptosis is a primary mechanism of GSH depletion-induced cell death in RPE (Fig
As a result, it plays a huge role in helping your body process toxins from your food and environment
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