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Timing of carbs: Some protocols inject fasted or away from large carbohydrate meals, since elevated insulin can blunt the GH pulse

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For example: Endogenous GHRH has a half-life of ~515 minutes Native GLP-1 is broken down in under 2 minutes Thats why natural peptides are rarely used directly in therapeutics theyre too unstable

Conditions that impair liver function reduce glutathione: Non-alcoholic fatty liver disease (NAFLD) Alcohol-related liver disease Hepatitis Medication-induced liver stress (acetaminophen, statins) 5