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Combining tretinoin with other medications Acne is often treated with a combination of two or more medications at the same time, which is commonly referred to as combination treatment. Combination therapy aims to address multiple factors that contribute to acne development, such as excess oil production, bacterial growth, inflammation, and abnormal skin cell shedding

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Microvascular pericytes are particularly important as they contribute to maintenance of the BBB, regulate cerebral blood flow, play a key role in generation of new blood vessels, aid microvessel stability, and clear waste from the brain [31]

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