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doi: 10.1152/physrev.00013.2014

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The nausea, bloating, or other digestive symptoms some people experience are temporary reactions to this slowed digestion not evidence of lasting harm

A 2024 review in the Journal of Clinical Investigation found no increased risk of pancreatitis or pancreatic cancer with long-term GLP-1 use

In contrast, long-acting agents appear to have a larger effect on lowering fasting glucose due to their effect to increase insulin release and inhibit glucagon release (Meier 2012)