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This temporal profile is mechanistically consistent with the rate at which high-dose Tyrosine's catecholamine synthesis support kicks in not instantaneous like caffeine, but progressive as the precursor pool is used for dopamine and norepinephrine synthesis.

[7] The released GH then acts on the liver and peripheral tissues to increase production of IGF-1, the mediator of many of GHs downstream effects

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Finally, these observations provide a unique example of an intervention which appears to favor female healthspan and lifespan, thereby reinforcing the need for considering sex differences in devising therapeutic strategies to treat aging and its diseases