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Environmental factors can slow down the conversion of methylfolate to folinic acidand vice versa

That influences their ability to mediate gut permeability

The literature search and selection process was conducted according to PRISMA guidelines, and the overall flow of records through identification, screening, and inclusion is presented in Supplementary Figure S1

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Together, these compounds allow researchers to explore overlapping aspects of central nervous system function, including neuropeptide signaling, stress-response modulation, circadian regulation, and the interface between aging biology and neuroendocrine control