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Metformin can increase the risk of a serious condition called lactic acidosis (too much lactic acid in the body)
Increased Adipose Protein Carbonylation in Human Obesity
It is important to note that ethnicity-adjusted BMI thresholds (e.g., 27.5 kg/m for certain ethnic groups) inform risk assessment and some referral criteria but do not automatically change medicine licensing criteria
The American Journal Of Cardiology 2004, 94: 279-283
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