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When GLP-1 agonists slow gastric emptying, large meals sit in the stomach longer, creating that heavy, nauseated feeling
This makes dosing straightforward for the typical protocol that starts at 0.25mg weekly
Blood pressure should be assessed regularly, as both weight loss from tirzepatide and the antihypertensive effects of beta blockers may necessitate adjustments in blood pressure medications to avoid hypotension
doi: 10.1016/j.cell.2012.03.042 18 Brigelius-FloheRMaiorinoM
Experimental models show that GLP-1 receptor activation suppresses microglial overactivation and pro-inflammatory cytokine signaling, while restoring diet-induced impairments in brain-derived neurotrophic factor (BDNF) pathways [21]
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