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The lid domain and glycine-rich loop are critical for ATP binding, which triggers major shifts in their conformations (Galant et al., 1999
It helps maintain muscle mass and a healthy metabolism
Nat Cell Biol (2012) 14(3):27686
In der metabolischen und endokrinologischen Forschung dient Tirzepatide als einzigartiges Werkzeug zur Untersuchung der Inkretin-Signalwege, der Glukosehomostase und der Regulation des Energiestoffwechsels
Funding was provided by Wellcome, the Medical Research Council, the European Union Horizon 2020 Program, the National Institutes of Health (grants U01-DK105535, U01-DK085545 and UM-1DK126185), the National Institute for Health Research Oxford Biomedical Research Centre, the Canadian Institutes of Health Research, the Novo Nordisk Foundation, Boehringer Ingelheim, and Diabetes Australia
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