Published studies suggest both compounds produce dose-dependent effects across these domains in preclinical models, with retatrutide showing additional signal on energy-expenditure readouts consistent with its GCGR arm
And new results this week of a landmark trial in people with cardiovascular disease showed Wegovy can reduce the risk of heart attack, stroke, or heart-related death by 20%, bolstering expectations for wider use of the medicine and, potentially, broader insurance coverage
After some weight loss is achieved and a person reaches a plateau, it is important to assess body composition. Data that is raising concern about sarcopenia as it relates to GLP-1 drugs is driven by a small portion of participants who underwent DEXA (dual-energy X-ray absorptiometry), which measures bone mineral density using spectral imaging, said Dr
The identification of other cues that induce such adaptive responses is imperative since the long-term efficacy of obesity treatments is low, in part due to bodys defense mechanisms that decrease energy expenditure during weight loss 7
Some studies show it might not be good for breast cancer patients