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PEM is a debilitating aspect of all three conditions, leading patients to pace their activities to avoid triggering these symptoms (Stussman et al., 2023

Another possible contributing mechanism is maladaptive neuroplasticity, in which neuronal pathways adapt and conform pathologically to changes in auditory system nerve signaling

Gilliland FD, Li YF, Gong H, Diaz-Sanchez D: Glutathione s-transferases M1 and P1 prevent aggravation of allergic responses by secondhand smoke

Patients with a history of cancer, or those with elevated cancer risk, should approach peptide therapy with particular caution and only under close medical supervision