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1988 Aug 29;238(2):343-346

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Adaptive increase in pyruvate dehydrogenase kinase 4 during starvation is mediated by peroxisome proliferator activated receptor alpha

This could explain why infection of mice with oral Trepomnema denticola bacteria induces Tau hyperphosphorylation and A accumulation in mice in the hippocampus with neuronal loss (Wu et al., 2022), and why filtrates of Helicobacter pylori bacteria induce Tau hyperphosphorylation in mouse neuroblastoma cells and rat brains via GSK-3 activation (Wang et al., 2014)

The large molecular weight (4,114 Daltons) and poor oral bioavailability make significant milk transfer biologically unlikely