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The 8 mg dose produced mean weight loss of approximately 22.8%, while the 4 mg dose achieved about 17.3% weight reduction

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Notably, these molecular changes were associated with an increase in melanin synthesis

Fremanezumab induced AEs: hair loss ( n =1), tachycardia ( n =1), numbness of the extremities ( n =1), choking sensation ( n =1), allergic reactions ( n =1), while constipation was reported in only one patient with erenumab

Greuter T, Vavricka S, Konig AO, Beaugerie L, Scharl M