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Alpha-lipoic acid treatment reduces the levels of advanced end glycation products in type 2 diabetes patients with neuropathy

A wide range of non-motor manifestations, including hyposmia or anosmia, gastrointestinal disturbances like chronic constipation, rapid eye movement (REM) sleep behavior disorder, autonomic dysfunction, mood changes like depression and anxiety, and progressive cognitive impairment, account for a significant portion of the disease burden [3]

Blocking EMT of bile duct cells alleviated bile duct ligation, inducing ductular reaction and biliary fibrosis in mice (93)

This adverse effect has not yet been clinically reported Hypopigmented patches, especially on sun-exposed areas have been observed after 1012 doses of intravenous injection by practitioners (unpublished observations)

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