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These substances can increase the risk of cardiovascular events, neurological effects, and addiction, prompting warnings to stop use and dispose of the products immediately

In an animal model extending 21 days, researchers identified: Lower levels of beneficial gut bacteria that help break down dietary fibre Reduced short-chain fatty acids which protect the gut lining and help regulate inflammation Higher levels of blood inflammatory markers An increase in liver weight, which can reflect low-grade inflammation A smaller caecum the part of the intestine where gut bacteria break down fibre and produce protective compounds Reduced levels of a brain-derived protein associated with cognitive impairment

Clinical trials of the coadministered regimen (CagriSema) show greater bodyweight reduction than either agent alone [2]

Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation