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The mice were given EGCG and vehicle-treated control groups, and their motor function was assessed

Concurrently, serum IL-1 levels dropped significantly, and caspase-1 and IL-1 expression decreased by over 80% ( Limitations: Although GGC supplementation replicated key phenotypes in vivo , the study did not include in vivo blocking verification for GGC generation/transport or the NLRP3 module

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doi: 10.3389/fnmol.2017.00033 Received 29 September 2016 Accepted 27 January 2017 Published 13 February 2017 Volume 10 - 2017 Edited by Ildik Rcz, University of Bonn, Germany Reviewed by Wei Chen, Beijing Institute of Pharmacology and Toxicology, China

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