Ipamorelin, a synthetic pentapeptide, appears to act as a selective agonist for the ghrelin receptor and may stimulate the release of GH
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Lifestyle factors including prolonged sedentary behavior, high-fat dietary patterns, and dysbiotic gut microbiota further suppress natural GLP-1 production
Importantly, multi-omic integration revealed that these effects are accompanied by decreased pro-inflammatory lipids, reduced collagen-derived metabolites, and increased levels of pro-resolving mediators, confirming metabolic restoration at multiple regulatory layers
