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Keywords: body weight, glycated hemoglobin (HbA 1c ), efficacy, glucagon-like peptide-1 receptor agonist (GLP-1RA), oral, semaglutide, subcutaneous, type 2 diabetes Introduction Evidence from trials and real-world studies in patients with type 2 diabetes (T2D) indicates that the risk of complications may be reduced by providing sustained glycemic control and that near-normal glycated hemoglobin (HbA 1c ) levels should be achieved as early as possible in the T2D trajectory (1, 2)

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