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Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease characterized by impaired insulin secretion, while type 2 diabetes mellitus (T2DM) is mainly caused by insufficient insulin secretion or insulin resistance

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Furthermore, the SGLT2-i hybrid diuretic effect, which combines natriuresis and osmotic diuresis, might also have cardioprotective properties leading to preload and myocardial stretch reduction (the diuretic hypothesis) (51)

They may help patients eat less without feeling constantly deprived, reduce food noise, improve portion control, and maintain better consistency over time

Diabetes and cardiovascular disease: epidemiology, biological mechanisms, treatment recommendations and future research